Evaluation of Konjac Glucomannan Asymmetric Membrane Containing Virgin Coconut Oil as Potential Wound Dressing Material

Abstract

The wound healing process consists of a series of highly complicated and dynamic events that restore the skin's structural integrity. Most commercial wound dressings are insufficient, expensive, or may interfere with wound healing, such as adhesive wound dressings that cause skin irritation when removed. Asymmetric membranes are now one of the most promising options for wound healing owing to its unique structural similarities to the epidermal and dermal layers of the original skin. Along with its intrinsic biocompatibility, antimicrobial, hemostatic, and therapeutic characteristics, Konjac glucomannan mixed with virgin coconut oil (VCO) distinguishes out among the many ingredients utilized to create these unique layers. The casting-freeze method was used to create an asymmetric membrane of konjac glucomannan containing VCO. Fourier transform infrared spectroscopy (FT-IR), Thermogravimetric analysis (TGA), and Differential scanning calorimetry were used to characterize the membrane (DSC). The FT-IR results revealed a significant intermolecular hydrogen bond interaction between KGM-NaOH and VCO. The thermogravimetric analyses revealed that the membrane samples were thermally stable. Furthermore, DSC results reveal that VCO has improved the thermal tolerance properties of KGM asymmetric membrane when virgin coconut oil concentration at 0.1%. Based on the result, the KGM-VCO asymmetric membrane has great potential to be applied as wound dressing.